Twain, Mark, Boyhood Home - View this location on map Described as perhaps the Midwest's outstanding literary shrine, this was the boyhood home (1844-1853) of Samuel Langhorne Clemens (1835-1910)--better known as 'Mark Twain'--humorist, novelist, and one of the better known literary figures of 19th century America. Clemens' life in this Mississippi River town had a great effect on his later literary career. 206-208 Hill Street, Hannibal, Missouri Historical, Cultural

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