Mission SLO - View this location on map The mission san luis obispo de tolosa ( 805-781-8220) was once the richest in california. its massive arched wooden doorway opens to reveal a long l-shaped sanctuary. just off it is a small and serene prayer room. light a candle for a loved one or a friend in need. New York Times 751 Palm St, San Luis Obispo, CA Historical,

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